DESIGNING STUDIES FOR DOSE RESPONSE
نویسندگان
چکیده
منابع مشابه
Robustness of design in dose–response studies
We construct experimental designs for dose–response studies. The designs are robust against possibly misspecified link functions; for this they minimize the maximum meansquared error of the estimated dose required to attain a response in 100p% of the target population. Here p might be one particular value—pD0:5 corresponds to ED50-estimation—or it might range over an interval of values of inter...
متن کاملMultiple Comparison Procedures in Dose Response Studies
Dose–response studies are useful in Phase II and Phase III clinical trials to evaluate efficacy and toxicity of a drug in order to determine its effective and safe ranges. A zero dose is generally included as a control against which higher doses are compared. This naturally leads to multiple comparisons. The ordered nature of doses suggests the use of stepwise multiple test procedures. The purp...
متن کاملTest for trend: evaluating dose-response effects in association studies
1. Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA. 2. Methods in Epidemiologic, Clinical and Operations Research–MECOR–program, American Thoracic Society/Asociación Latinoamericana del Tórax. 3. Divisão de Pneumologia, Instituto do Coração – InCor – Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São P...
متن کاملSummary of dose-response modeling for developmental toxicity studies.
Developmental toxicity studies are an important area in the field of toxicology. Endpoints measured on fetuses include weight and indicators of death and malformation. Binary indicator measures are typically summed over the litter and a discrete distribution is assumed to model the number of adversely affected fetuses. Additionally, there is noticeable variation in the litter responses within d...
متن کاملBayesian dose-response analysis for epidemiological studies with complex uncertainty in dose estimation.
Most conventional risk analysis methods rely on a single best estimate of exposure per person, which does not allow for adjustment for exposure-related uncertainty. Here, we propose a Bayesian model averaging method to properly quantify the relationship between radiation dose and disease outcomes by accounting for shared and unshared uncertainty in estimated dose. Our Bayesian risk analysis met...
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ژورنال
عنوان ژورنال: Statistics in Medicine
سال: 1996
ISSN: 0277-6715,1097-0258
DOI: 10.1002/(sici)1097-0258(19960229)15:4<343::aid-sim163>3.0.co;2-f